E-selectin, as compared to L-selectin and P-selectin, is the redundancy of ligands through which it tethers PMN and executes a slow rolling immunosurveillance at velocities on the order of one micron per second. Another remarkable feature is that PMN rolling on E-selectin and subsequent ESL clustering transduce
Estrutura. Os tres membros coñecidos da familia da selectina (L-, E- e P-selectina) comparten unha estrutura en casete similar: un dominio de lectina dependente de calcio N-terminal, un factor de crecemento epidérmico dominio de tipo EGF, un número variable de unidades repetidas consenso (2, 6 e 9 para as L-, E- e P-selectina, respectivamente), un dominio transmembrana (TM) e unha cola
Regulation of P-selectin expression was analyzed under multiple conditions; see all results 1990-08-01 · View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR033991, Selectin_CTLD IPR002396, Selectin_superfamily IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom: Pfam i 38 e-selectin Primary Antibodies: Thermo Fisher antibodies are validated for applications including western blotting, immunocytochemistry, flow cytometry, and chromatin immunoprecipitation. Evidence-based information on P selectin from hundreds of trustworthy sources for health and social care. P-Selectin cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each P-Selectin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector. 1 reviews. Compare Anti-E-selectin Antibody Products from leading suppliers on Biocompare.
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Blocking of selectins is therefore considered a promising therapeutic approach to treat E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists. Binder FP (1), Ernst B. Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising 2002-07-01 During P- and E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole ligand for P-selectin and one of the ligands for E-selectin. P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. The three selectins, E-selectin (CD62E), L-selectin (CD62L) and P-selectin (CD62P), are related both structurally and functionally.
L-1 also plays a crucial role in T-cell homeostasis by binding to lymphoid chemokines, and can induce tolerance by enhancing the functions of regulatory T cells. Recent findings PSGL-1 was originally described as a leukocyte ligand for P-selectin, but it is actually a ligand for all selectins (P-, L- and E-selectin), binds chemokines, activates integrins and profoundly affects T-cell biology
Compatible samples: cell culture supernates, serum and Hrsg . von P. Langenscheidt . Wulffen , E. , Psychologie des Verbrechers .
75 (1), p. 123-132. Artikel i vetenskaplig tidskrift. 2021. Open Access icon e-selectin, and endostatin in an exploratory study in men with prostate cancer healthy subjects after intake of whole-grain rye porridges versus refined wheat bread.
Binds to COS cells transfected with human E-Selectin or human P-Selectin. It does not bind to CHO cells Gene and protein expression of P-selectin and ICAM-1 were studied at 0.5, 1, 6, 12, (L-selectin), platelets (P-selectin), and endothelial cells (P- and E-selectin). intensity comparison of 28S expression versus each cytokine with P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells METHODS:: Herein, we used a graft-versus-host disease (GvHD) model to study CD8 Inhibition of E-selectin had no effect on GvHD-induced CD8 av L Dieterich · 2011 · Citerat av 2 — teractions by increasing surface E-selectin. Manuscript. IV Dieterich L.C. teins facilitating leukocyte-endothelial adhesion, including P-selectin and von.
There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector. 2021-03-19
2016-12-06
Human E-Selectin/P-Selectin (CD62E/P) Fluorescein-conjugated Antibody .
Apa rubriker
This adhesion is 2b) (P < 0.05 versus LPS-Gal plus PBS, n = 7 to 9). Again, neither the anti-E- nor the anti-L-selectin antibody altered leukocyte adhesion. Importantly, 13 Oct 2017 E-selectin is primarily expressed on endothelial cells [2], and mediates slow, steady rolling adhesion [3], whereas L-selectin is constitutively 2 Aug 2018 Although endothelial cell adhesion molecules (CAMs) are postulated to play a key role in early atherosclerosis, studies on endothelial CAMs 25 Feb 2013 Measurements were made in five contact durations to obtain a Pa vs. t binding curve for each receptor-ligand pair respectively expressed on the In addition to ICAM-1, the selectin family of adhesion molecules influences PMN– endothelial cell interaction. The selectins designated L-, P-, and E-selectin are a be mediated by E- and P-selectin binding to carbohydrate.
P-Selektin ist ein Protein, das als Zelladhäsionsmolekül (CAM) auf den Oberflächen von aktivierten Endothelzellen und Thrombozyten fungiert. In inaktiven Endothelzellen wird es in Zellgranula gespeichert, die Weibel-Palade-Körperchen genannt werden, in inaktiven Thrombozyten in den α-Granula . E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins. E-selectin gained a new role since it was demonstrated to be involved in cancer cell trafficking, stem-like properties and therapy resistance.
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Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice. R G Collins et. al Blood, 98(3), undefined (2001-7-27)
They have been extensively studied due to their role in the inflammatory response and their potential use as therapeutic targets. E-selectin, also known as CD62 antigen-like family member E, endothelial-leukocyte adhesion molecule 1, or leukocyte-endothelial cell adhesion molecule 2, is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene. 1997-02-01 · Recently, several groups have reported that PSGL-1 might also serve as a ligand for E-selectin.